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Members of the same family in Italy possess a rare genetic an anomaly that allows them to completely not feel physical pains. European scientists intend to study these people and try ultimately find an effective way to deal with chronic pains.
A condition called congenital analgesia characterized by a decrease or complete absence of pain sensitivity, not desirable for humans since pain is important component of the mechanism of human self-preservation. However patients experiencing torment, with pleasure would refuse such sensitivity, at least for a while.
An individual with congenital analgesia easily determines the difference between cold and heat, sharp and dull objects. Not less, he is not able, for example, to determine that the drink is too hot and burns his mouth, or he stepped on the glass. Nerves of this people are in place, but do not work properly. And in the Italian family of Marsili all six blood relatives “suffer” from this condition. Surname consists of 78 year old a woman, her two middle-aged daughters and three grandchildren: two boys and one girl. Amazing family at the moment examined by British experts.
Find the cause of pain insensitivity
Dr. James Cox of the University of London tells us that elderly Leticia Marsili broke her shoulder last year while riding skiing. She did not notice this and continued to ride all day, after why she came home and went to bed calmly. Only after a few days when the Italian made a planned visit to the hospital, doctor He diagnosed her with a fracture and began his treatment. According to scientists, now the Marcily family is undergoing experiments that can recall torture. Italians are pricked with needles, subjected to excessive high and low temperatures, fed the sharpest chili peppers and everything like that.
People of science have already determined that these relatives have an incredibly rare mutation in the ZFHX2 gene. He is responsible for ensuring that peripheral impulses correctly converted sensitive to pain in parts of cells into signals for the brain. When the researchers corrected this gene to laboratory mice, in animals also changed mechanism of perception of pain. Rodents stopped recognizing the cold and heat, and also respond to some pain stimuli. Experts hope that understanding how to turn off a person a sense of pain will allow them to develop a new generation painkillers.
