Italian family does not feel pain at all

Members of one family in Italy have a rare genetic
an anomaly that allows them not to feel physical at all
the pains. European scientists intend to study these people and try
eventually finding an effective remedy to combat chronic

A condition called congenital analgesia, characterized by
decrease or complete absence of pain sensitivity, not
desirable for a person because pain is important
component of the mechanism of human self-preservation. However, patients
tormented, would gladly refuse such
sensitivity, at least for a while.

An individual with congenital analgesia can easily determine
the difference between cold and heat, sharp and dull objects. None
however, he is not able, for example, to determine that a drink is too
hot and burns his mouth, or he stepped on the glass. Nerves such
people are in place, but working incorrectly. And in
Italian family Marsili all six blood relatives
�“Suffer” from such a condition. Surname consists of 78 year old
women, her two middle-aged daughters and three grandchildren: two
boys and one girl. At the moment, an amazing family
surveyed by British experts.

Find the cause of pain insensitivity

Dr. James Cox of the University of London tells us that
Elderly Leticia Marsili broke her shoulder last year while riding
skiing. She did not notice this and continued to ride all day after
she came home and went to bed quietly. Only a few later
days when the Italian made a scheduled visit to the hospital, the doctor
diagnosed her with a fracture and began his treatment. According to scientists,
Now the Marsili family is undergoing experiments that
remind torture. Italians are pricked with needles, excessively
high and low temperatures, fed the hottest chili peppers and
everything like that.

People of science have already determined that these relatives are present.
an incredibly rare mutation in the ZFHX2 gene. He is responsible for
peripheral impulses are correctly transformed sensitive to
pains by cell parts signals to the brain. When researchers
corrected this gene in laboratory mice, in animals, too, has changed
механизм восприятия the pains. Rodents stopped recognizing cold and
heat and also respond to some pain stimuli.
Experts hope that understanding how to disable a person
the feeling of pain will allow them to develop a new generation
pain medication.

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