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This development, writes ACS Nano magazine, represents an important event in the field of theranostics – this term is called nanoparticles capable of diagnosing and treating disease.
Iron oxide nanoparticles that can track the process drug delivery, make it possible to adapt treatment methods individual patients. Realizing how a drug is released into cancer cells and how it acts on them and on surrounding tissues, doctors can adjust the dose to achieve the best result.
Group of Associate Professor Cyril Boyer of the Institute of Chemical Engineering first showed the “in vivo fluorescence” method in action, controlling the process of drug delivery to laboratory cell lines lung cancer.
Previously, similar studies were carried out in the course of model experiments, so it was important to know their kinetics in the present biological environment.
Magnetic iron oxide nanoparticles have been well studied because of their widely used as contrast agents in magnetic resonance imaging (MRI). A few last developments allowed to associate drugs with them.
Previously, there were separate studies on application methods. drugs on the surface of the nanoparticles, and not one that would proved the efficacy of drug delivery inside cancer cells.
According to a recent study, scientists have found a new way applying drugs to the polymer coating of nanoparticles iron oxide and first demonstrated their delivery inside cells.
Now, researchers intend to implement the invented method in practice.
Oncology
