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American scientists (Johns Hopkins University) created glutamine metabolism blocking drug that promotes the growth of a cancerous tumor. In addition, the drug JHU083 transforms the microenvironment of cancerous tumors, opening them to immune system and thereby making it vulnerable. Reports Edition MedicalXpress.
Developed drug that mimics the work of an antagonist glutamine DON, accumulates in malignant tissues neoplasms. Glutamine is known to stimulate rapid growth of neoplasms.
JHU083 has already been tested on mouse models. colon cancer, melanoma and lymphoma. Experts believe that this compound can affect the microenvironment hostile malignancy immune cells due to acidity, lack nutrients and oxygen.
Using Compound JHU083 Reduces Malignant Growth neoplasms and improves survival. Some rodents had marked long remission, which is caused by high activity the immune system. When the mice were injected with cancer cells, then formed powerful immune memory their body just torn away.
Andrey Vetrov
Oncology
