American scientists have identified a genetic variation that affects the biological clock so much that it can indicate what time of day is most likely to die person. Open Source Photo by Andrew Lim Beth Israel Medical Center (Boston, USA) found that internal biological clocks affect the time of onset of acute clinical conditions such as stroke or heart attack. Lim and him colleagues searched for genetic traits indicating increased risk of developing Alzheimer’s disease or disease Parkinson’s. The study involved about 1.2 thousand people. over 65 years old. All of them constantly wore a special bracelet, which recorded a change of sleep and wakefulness. Study accepted an unexpected turn when scientists deciphered the genomes of the participants experiment. It turned out that the “larks” are people prone to early get up and fall asleep early, has genetic differences from “owls” – those who tend to sleep longer in the morning and stay up later in the evening. The Lim group found a single nucleotide (nitrogenous base, “brick” of the DNA molecule) next to the “Period 1” gene, which different in “larks” and “owls.” About 60% of people in this the point is adenine (A), and 40% have guanine (G). Since man is the owner of a double set of chromosomes, then each of us owns A-A, G-G or A-G. As it turned out, people with A-A woke up about an hour earlier than carriers G-G combinations, and those who had an A-G record in the genome – for half an hour later than the first. When the researchers analyzed deaths among the participants in the experiment (many of whom joined him 15 years ago, at the age of 65), they found out that this genetic variation may indicate the hour of death. People with A-A or A-G in the genotype died shortly before 11 am, like most people, while G-G carriers on average died shortly before 6 o’clock in the evening. Lim notes that additional studies to determine the mechanisms that bind one or another genetic features with biological features hours.
DNA time